Open PhD position – ESR 07
The effect of malnutrition and polypharmacy in aging on gastrointestinal (GI) transit time, gastric fluid emptying and pH
Planned starting date: 01 May 2021
Host Institution: Katholieke Universiteit Leuven, Belgium (J. Tournoy, I. Spriet)
PhD Awarding Institution: Katholieke Universiteit Leuven, Belgium
Gastrointestinal factors such as pH and transit times are important determinants for drug absorption. Age-related motility and pH changes, but also malnutrition and the use specific drug classes are assumed to influence these GI factors. These factors are highly prevalent in geriatric patients. Hence, we will investigate the influence of the former on pH and transit times by means of clinical studies using the Smartpill or salivary tracer techniques. The data will further be used in in vitro tools and PBPK modelling in order to predict the effect on oral drug absorption in older patients in collaboration with Abbvie and the consortium.
- Assess the effect of (i) advanced age, (ii) malnutrition and (iii) the intake of neuroleptics and anticholinergics on transit times, gastric fluid emptying and pH in geriatric patients.
- Assess the relevance of these effects on oral drug absorption by applying the in vivo data in (i) biorelevant in vitro tools and (ii) PBPK modelling.
Expected Results: New knowledge on the effect of frequently used drugs and malnutrition (common in older age) on transit times and GI pH levels. The project will provide reference data to improve in vitro tools and PBPK modelling.
- AbbVie Deutschland GmbH & Co KG, Germany (M. Koziolek)
Master’s degree in pharmaceutical or (bio)medical sciences or equivalent.
Experience in (old age) medicine and/or pharmacokinetics.
Graduated cum laude or higher in order to enter the KULeuven PhD program, preferentially a Dutch speaker, or willing to learn Dutch.