This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956146.

Outreach

Elderly people illustrated

Publications

DOI:
Eksteen, G., Steenackers, N., Van der Schueren, B., Vanuytsel, T., and Matthy, C.  Selenium Deficiency After Bariatric Surgery Is More Than Surface Deep. Obes. Surg., 32(7):2476 (2022).

DOI:
Stillhart, C., Asteriadis, A., Bocharova, E., Eksteen, G., Harder, F., Kusch, J., Tsakri, T., Augustijns, P., Matthys, C., Vertzoni, M., Weitschies, W., and Reppas, C. The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review, Eur. J. Pharm. Sci. 187:106452 (2023).

DOI:
Hummler, H., Stillhart, C., Meilicke, L., Grimm, M., Krause, E., Mannaa, M., Gollasch, M., Weitschies, W., Page, S. Impact of Tablet Size and Shape on the Swallowability in Older Adults. Pharmaceutics, 15(4):1042 (2023).

DOI:
Hummler, H., Sarwinska, D., Weitschies, W., Gollasch, Maik, and Page, S. Parameters to Consider for Successful Medication Use in Older Adults. Eur. J. Pharm. Sci., 187:106453 (2023).

DOI:
Hummler, H., Page, S., Stillhart, C., Meilicke, L., Grimm, M., Mannaa, M., Gollasch, M., Weitschies, W. Influence of Solid Oral Dosage Form Characteristics on Swallowability, Visual Perception, and Handling in Older Adults. Pharmaceutics, 15(4): 1315 (2023).

DOI:
Edwina, A., Dia, N., Dreesen, E., Vanassche, T., Verhamme, P., Spriet, I., Van der Linden, L., Tournoy, J. Insights into the pharmacokinetics and pharmacodynamics of direct oral anticoagulants in older adults with atrial fibrillation: a structured narrative review. Clin. Pharmacokinet. 62(3):351-373 (2023).

DOI:
Demeester, C., Robins, D., Edwina, A., Tournoy, J., Augustijns, P., Ince, I., Lehmann, A., Vertzoni, M., and Schlender, J. Physiologically Based Pharmacokinetic (PBPK) Modelling of Oral Drug Absorption in Older Adults. Eur. J. Pharm. Sci. 188:106496 (2023).

DOI:
Tzakri, T., Rehenbrock, L., Senekowitsch, S., Rump, A., Schick, P., Krause, J., Kromrey, M.-L., Grimm, M., Weitschies, W. Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics. Pharmaceutics. 15(11):2584 (2023)

DOI:
Edwina A., Dreeseb E., Hias J., Koch B., Van den Eede N., Pauwels S., Allegaert K., Van der Linden L., Spriet I., Tournoy J. Agreement Between a Colorimetric Assay and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Quantifying Paracetamol Plasma Concentration. AAPS J. 26(1):23 (2024).

Conference presentations

Hummler H.  Acceptability of Solid Oral Dosage Forms in Older Adults , 6th APV Winterkonferenz, 19 January 2023, Salzburg, Austria (oral presentation).

Hummler H. Impact of Size and Shape on the Preferences of Solid Oral Dosage Forms in Older Adults, 4th European Conference on Pharmaceutics, 20 March 2023, Marseille, France (poster).

Sarwinska D. Real-life dosing conditions in geriatric patients,4th European Conference on Pharmaceutics, 20 March 2023, Marseille, France (conference abstract).

Tzakri T., Rehenbrock L., Senekowitsch S., Rump A., Schick P., Krause J., Grimm M., and Weitschies W. Compression-coated tablet for the determination of gastric water emptying: development and in vivo validation, 4th European Conference on Pharmaceutics, 20 March 2023, Marseille, France (oral presentation).

Edwina A., Dreesen E., Hias J., Koch B., Van den Eede N., Pauwels S., Allegaert K., Van der Linden L., Spriet I., Tournoy J. Comparison of a colorimetric assay and ultra-performance liquid chromatography tandem mass spectrometry for quantifying paracetamol plasma concentrations: design of a geriatric pharmacokinetics study, American Society of Clinical Pharmacology and Therapeutics, 22 March 2023, Atlanta, Georgia, United States (poster).

Harder F. The effect of sparkling water on the systemic pharmacokinetics of paracetamol in the elderly, 21st Forum of Pharmaceutical Sciences – Belgium Society of Pharmaceutical Sciences, 27th April 2023, Blankberge, Belgium (oral presentation).

Kusch J. Impact of aging on relative gene expression of tight junction proteins in duodenal and colonic epithelium: preliminary data,  AAPS PharmaSci 360, 22th October 2023, Orlando, Florida, United States (poster).

Hummler H. Acceptable Solid Oral Dosage Forms for Older Adults as Prerequisite for Medication Adherence – The Current Situation, AAPS PharmaSci 360, 22th October 2023, Orlando, Florida, United States (conference abstract).

Asteriadis A. Cognitive impairment on the physicochemical characteristics of fasting gastric contents of individuals in andavanced age: Initial data, AAPS PharmaSci 360, 22th October 2023, Orlando, Florida, United States (conference abstract).

Bocharova E. Clarifying the impact of advanced age on the physicochemical characteristics of gastric contents in the fasted state, AAPS PharmaSci 360, 22th October 2023, Orlando, Florida, United States (conference abstract).

Robins D. Expanding the Application of Global Sensitivity Analysis for Risk Assessment in Special Populations, 14th American Conference on Pharmacometrics, 6th November 2023, Maryland, United States (poster).

Hummler H. Influence of coating materials on the esophageal transit, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18-21 March 2024, Vienna, Austria (conference abstract).

Harder F. The effect of sparkling water on the systemic pharmacokinetics of paracetamol in older adults. 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18-21 March 2024, Vienna, Austria (conference abstract).

Tzakri T. The use of a caffeine formulation and salivary kinetics as a non-invasive method of measuring gastric water emptying. 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18-21 March 2024, Vienna, Austria (conference abstract).

Asteriadis A. Physochemical characterization of fasting duodenal contents of older adults with moderate cognitive impairment and comparison with data in young adults: Initial data. 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18-21 March 2024, Vienna, Austria (poster).

Bocharova E. The impact of advanced age on the physicochemical characteristics of duodenal contents under fasting conditions: Initial data. 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18-21 March 2024, Vienna, Austria (conference abstract).

Sarwinska D. Real-life dosing conditions in older adults and geriatric patients – a biophamaceutical perspective. 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18-21 March 2024, Vienna, Austria (conference abstract).

Demester C. A Retrospective Quantification of Gastric and Duodenal Fluid Volumes of Older Adults using Magnetic Resonance Imaging (MRI). 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18-21 March 2024, Vienna, Austria (conference abstract).

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