Assess the effect of advanced age and of Alzheimer’s disease on drug disposition in older people and in geriatric patients with Alzheimer’s disease in relation to intestinal transporters and enzymes. Gastrointestinal drug and formulation behavior will be explored using the GI-sampling technique (relevant examples: see http://ungap.eu/GIsampling).

Expected Results: Unique insight into alterations in drug disposition in older people and geriatric patients with Alzheimer’s disease. In particular: (i) new reference data on GI drug behavior and the abundancy and activity of intestinal transporters and enzymes; (ii) improved PBPK models to evaluate transporter- and/or enzyme-mediated intestinal drug absorption and drug-drug interactions.