This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956146.

Open PhD position – ESR 08

Intestinal drug disposition in older people and in geriatric patients with Alzheimer’s disease

Planned starting date: 01 May 2021

Host Institution: Katholieke Universiteit Leuven, Belgium (P. Augustijns, T. Vanuytsel)

PhD Awarding Institution: Katholieke Universiteit Leuven, Belgium

Project Description

Assess the effect of advanced age and of Alzheimer’s disease on drug disposition in older people and in geriatric patients with Alzheimer’s disease in relation to intestinal transporters and enzymes. Gastrointestinal drug and formulation behavior will be explored using the GI-sampling technique (relevant examples: see http://ungap.eu/GIsampling).

Expected Results: Unique insight into alterations in drug disposition in older people and geriatric patients with Alzheimer’s disease. In particular: (i) new reference data on GI drug behavior and the abundancy and activity of intestinal transporters and enzymes; (ii) improved PBPK models to evaluate transporter- and/or enzyme-mediated intestinal drug absorption and drug-drug interactions.

Planned Secondment

  1. Merck Healthcare KGaA, Germany (A. Lehmann)

Background

Essential Background
Master’s degree in Pharmaceutical Sciences or in Biomedical Sciences.

Desirable Background
Master thesis work and/or experience in pharmaceutical sciences.

Local Requirements
Applicants should possess a university degree.