This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956146.

Open PhD position – ESR 11

Development of open access PBB/PBPK models to predict oral drug absorption in Geriatric Patients and Older People

Planned starting date: 01 August 2021

Host Institution: Bayer AG, Germany (J.-F. Schlender)

PhD Awarding Institution: Katholieke Universiteit Leuven, Belgium

Project Description

Inform an open-source PBB/PBPK database on the basis of in vitro and in vivo data, setting a distinction between age- and/or disease-related impact on drug absorption. Generate evidence for PBB/PBPK modelling and simulation towards older people by defining distinctive case examples to qualify the approach for the intended use.

Expected Results: Mechanistically inform and holistically understand oral absorption changes with ageing and concomitant disease progression by integrating data generated by AGePOP ESRs-1-9 into a whole-body PBB/PBPK model. The project outcome will be perpetuated in an open-source PBPK software facilitating further research beyond the project context.

Planned Secondment

  1. Katholieke Universiteit Leuven, Belgium (P. Augustijns)


Essential Background
Master’s degree (or equivalent graduation) in relevant area (e.g. pharmacy/pharmaceutical sciences, natural sciences, medicine, engineering, and/or mathematics).

Desirable Background
First insights into programming language (e.g. R, Matlab) are beneficial but not a must. Experience with mechanistic modelling and parameter estimation in ODE systems would be an advantage.