Simone Hansmann
Principal Scientist Research Pharmaceutics, Merck Healthcare KGaA
(Co-)lead of WP3 and (co-)supervisor of ESR 10.
Dr. Simone Hansmann is a Pharmacist by training and graduated from Goethe University in Frankfurt/Main (Germany) in 2013. She conducted her PhD research in the labs of Jennifer Dressman with a focus on the prediction of oral absorption of weakly basic compounds with Physiologically-based Pharmacokinetic (PBPK) models. In 2017, she started an external Post-Doc position at Merck KGaA in the Centre of Excellence (CoE) Biopharmaceutics within the pre-formulation group continuing her work on absorption modeling. In 2018, she joined Merck KGaA as an expert in the CoE Biopharmaceutics and is now working as a lab head in this group. In her function, she is responsible for performing absorption predictions for new drug candidates in early and late- stage development and she supports pre-formulation work for early NCE projects as discovery CMC-Lead. She is an active member of the COST action UNGAP (Understanding Gastrointestinal Absorption-related Processes) and contributor to the IQ consortium Formulation and Bioperformance prediction working group.
Publications
- Hansmann, S., Miyaji, Y. and Dressman, J. (2018) An in silico approach to determine challenges in the bioavailability of ciprofloxacin, a poorly soluble weak base with borderline solubility and permeability characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 122, pp. 186-196. DOI: 10.1016/j.ejpb.2017.10.019
- Darwich, A. S., Margolskee, A., Pepin, X., Aarons, L., Galetin, , Rostami-Hodjegan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., Karlsson, E., Murphy, D., Tannergren, C., Thorn, H., Yasin, M., Mazuir, F., Nicolas, O., Ramusovic, S., Xu, C., Pathak, S. M., Korjamo, T., Laru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E., He, H., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Van Peer, A., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M.A., Brown, J., Lennernas H. and B. Abrahamsson (2017) IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes. European Journal of Pharmaceutical Sciences, 96, pp. 626-642. DOI: 10.1016/j.ejps.2016.09.037
- Margolskee, A., Darwich, A. S., Pepin, X., Aarons, L., Galetin, A., Rostami-Hodjegan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., Karlsson, E., Murphy, D., Tannergren, C., Thorn, H., Yasin, M., Mazuir, F., Nicolas, O., Ramusovic, S., Xu, C., Pathak, S.M., Korjamo, T., Laru, J., Malkki, J., Pappinen, S., Tuunainen, J. Dressman, J., Hansmann, , Kostewicz, E., He, H., Heimbach, T., Wu, F., Hoft, C., Laplanche, L., Pang, Y., Bolger, M.B., Huehn, E., Lukacova, V., Mullin, J.M., Szeto, K.X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Van Peer, A., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M.A., Brown, J., Lennernas, H. and B. Abrahamsson (2017) IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results. European Journal of Pharmaceutical Sciences, 96, pp. 610-625. DOI: 10.1016/j.ejps.2016.10.036
- Hansmann, S., Darwich, A., Margolskee, A., Aarons, L. and Dressman, J. (2016) Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models. Journal of Pharmacy and Pharmacology, 68(12), pp. 1501-1515. DOI: 10.1111/jphp.12618